How Can I Get My Science Project on the International Space Station?

19 Jul

Several weeks ago I attended the 1st Annual International Space Station (ISS) Research and Development Conference in Denver, Colorado, coordinated by the American Astronautical Association in cooperation with NASA and the Center for the Advancement of Science in Space (CASIS). There were almost 400 in attendance with a good portion of the crowd having no experience with flying space research. It was really great to see so many new people interested in space!

The purpose of the three day conference was to showcase the exciting science and R&D possibilities of the ISS and provide an outline of funding sources and routes to getting your projects on the ISS. The first two days centered on previous and current ISS experiments, covering topics from life sciences, fluid dynamics, materials R&D, developing more efficient environmental and life support systems, to hyperspectral imaging devices and results from the well known Alpha Magnetic Spectrometer. The last day consisted of workshops showing potential users the pathways to implement the ISS for research and an overview of NASA’s Small Business Innovation Research program.

The Alpha Magnetic Spectrometer #2 attached to the ISS.

Since I couldn’t possibly cram all the cool science I heard about into one post (you can find a good overview here), I thought I would present a run through of possibly something more beneficial: how to get your project on the ISS.



Science on the ISS? Me?
Do you need to be a genius to get your research on the ISS? Don’t tell anyone, but not really. If you have a unique, testable idea that can’t be carried out on Earth you stand a good chance of having your project funded and NASA will pay for the ride. How cool is that?

For ideas, there is always the obvious micro-g element, but your experiment could make use of the excellent vantage point of 220 miles above Earth for new geographical observations or with access to external platforms one could test things in the extreme heat, cold, radiation, and what astronaut Don Pettit refers to as “a vacuum with infinite pumping capability” of the space environment. Inside, the ISS is a well implemented laboratory with almost everything available that you would find in a research lab on Earth. For inspiration, comb through the ample amount of information on past projects at the ISS research website. With the ISS now averaging six crew members, about 35 hours/week are dedicated to doing science projects. Overall, the universe can literally be your playground and you have astronauts do your bidding. Mwah.

ESA Astronaut Andre Kuipers places samples into the station’s -80C freezer.

No Bucks, No Buck Rogers
O.K. so say you came up with an awesome idea, now what? Like all science or R&D, it’s expensive and even Elon Musk needed help getting his dream off the ground. Luckily, as an American researcher there are two sources of support for your ideas: NASA or CASIS.



NASA
NASA is interested in sponsoring research in several focused and practical areas that support their mission: human health, technology testing for enabling future exploration, life and physical sciences, and earth and space science. Funding opportunities are through solicitations posted throughout the year on the NASA Solicitation and Proposal Integrated Review and Evaluation System (NSPIRES) website. If selected, NASA sees you as a partner in helping to accomplish their science and technological goals. A typical NSPIRES review and selection process takes about 200 days.

NSPIRES Solicitations as of July 2012.

These peer reviewed proposals can be well funded and are sometimes for multi-year sessions. This route does require a bit of “practice” and I suggest first timers spend a fair amount of time familiarizing themselves with the process beforehand, either by using the tutorial and FAQ pages or by getting help from someone who has experience with the process. Also, being a government agency, NASA requires that your organization be registered with the Central Contract Registration (CCR) before submitting a proposal. I’ve also found NSPIRES solicitations come with little to no warning (the “Future Solicitations” box is always empty) and often give a short time to prepare. My advice is check the site often (or sign up for notification e-mails) and always have something ready to go.



CASIS
In 2005 Congress designated the US portion of the ISS as a national laboratory and in 2010 signed the NASA Authorization Act providing funds “to support international and commercial collaboration and growth, research, and technology development to maximize the scientific return on the significant investment in the ISS.” Upon completion of the ISS, NASA awarded the nonprofit CASIS as the entity responsible for managing the national laboratory as well as acting as a conduit between NASA and the commercial, nonprofit, academic, government agencies and individual researchers wanting to perform science and technology R&D on the ISS. With $3 million dollars a year set aside for research, CASIS is well positioned to do just that.

How is this different than the NASA route? There are simply more options: you can obtain support through a CASIS proposal solicitation; use your own funding (i.e. NIH, NSF, or donations); you can submit an unsolicited proposal; and lastly other government agencies (i.e. DOD) can also use this path.

Due to limiting resources (launch opportunities, lab space, crew time, etc.), CASIS evaluates and prioritizes all proposals with a scientific and economic review. This is essentially the same kind of process any researcher would go through to gain access to any national lab facility, say a synchrotron for example. There is also a business evaluation team in place to help highly rated proposals find funding.

CASIS’ Proposal Submission Page

Currently, CASIS proposal interests are focused on biosciences, with their first ever call for solicitations posted in early July 2012 for protein crystallography in microgravity. Future bioscience requests will be focused on creating animal models for studying the effects of micro-g on living things (i.e. osteoporosis, muscle wasting), as well as a studies on immune functions.

CASIS is so new I can’t give you my opinion of their process, but I can tell you from interacting with their personnel, they are fully committed to helping you get your experiments on the ISS and in the fastest way possible. The process appears more streamlined than NSPIRES, and has a typical “acceptance to launch” time of around 18 months. I honestly love the idea that through CASIS, essentially any researcher, business, or entrepreneur with a great idea can fly on the ISS at an unprecedented speed (pun intended).

I Have a Brilliant Idea and Funding, I’m Ready for Launch!
Don’t blow your hold-down bolts just yet. It’s highly recommended that you work with an “implementation partner” (IP) to assist you with your science or R&D project. IP’s have decades of expereience that can help you in either designing and building a flight-worthy experimental apparatus or provide you with one that is already made to spec.

NASA astronaut Nicole Stott does her best Vanna White for the Mouse Drawer System.

Say you have a project that involves mice, there are a few IP’s that already have flight ready mice habitats that you could use. Another advantage of an IP is that they handle most of the legendary 12 inches of paperwork required for flight, so you can focus strictly on your research design. I’ve done the paperwork once, and believe me it’s worth every penny to have the experts do it.


Poll Completed. You Are Go for Launch!
I hope this quick overview demonstrates that science and R&D on the ISS is a tangible goal. There are currently more opportunities than ever before, with NASA and CASIS wanting considerably to help facilitate your ISS project objectives. So, if you have ever been even remotely interested in space science, I greatly encourage you to give it a try. We can’t let the astronauts have all the fun up there, right?

Help Make “Meet a Scientist Monday” Better

28 May

I have done 22 “Meet a Scientist Monday” (MSM) interviews with the last 12 being podcasts. The podcasts alone have been downloaded almost 2,000 times. That goes far beyond my imagination and I sincerely thank everyone who has supported MSM.

The one thing that has been missing though is feedback. I’ve received little to no criticism about the podcasts and I’m really curious to how you feel about them. I am not the best interviewer and am always looking for ways to improve. I would love some criticism on what I’m doing well and what stinks. Is the style of the interview engaging and interesting? What kind of question you would like to hear?

Secondly, my time has become seriously constrained and I simply lack the freedom anymore to contact, schedule and interview all of the people I think are cool scientists. I figure the best way to handle this is to have fewer MSM podcasts, but I would like your help on choosing what scientist you would like to hear from. More local scientists? What kind of science fields interest you? Big name scientists? More Space Science? Less Space Science?

Overall, I’m asking you what is the best way to continue with MSM. If you haven’t heard any of the podcast, please take some time and listen and tell me what you think.

All “Meet a Scientist Monday” found HERE.

Thanks!!

Meet a Scientist Monday #22: Darren Boehning

13 Feb

Howdy! Today’s guest is Dr. Darren Boehning from The University of Texas, Medical Branch at Galveston, Texas.

Dr. Darren Boehning from UTMB


Learn more about apoptosis and Alzheimer’s Disease.

More information of the Boehining Lab’s Research.

Follow Darren on Twitter: @boehninglab

I hope you enjoyed this podcast of MSM. Please let me know what you think of it, good, bad, or ugly by commenting below.

If you are a scientist/engineer, I would love to have you participate in MSM! Send me an e-mail at: proteinwrangler@gmail.com

To begin Podcast, press the arrow below:

#WeAreScience

30 Jan

One of the reasons I started the “Meet a Scientist” series was to try and show that scientists are normal people, not the usual stereotypes you often see in the media. For me, one of the most surprising things to come out of that series were the pathways my colleagues had taken to reach their science careers. Thinking I had a strange path was completely wrong. It actually seemed to be the norm.

My first realization that I wasn’t alone was last year while interviewing Dr. Stephen Curry. He mentioned he was working on a film called “I’m A Scientist” and how he wanted to show non-scientists that we are all not geniuses or Nobel Prize winners, but just people. Curious and very stubborn people. He did a brilliant job and if you haven’t seen it, please watch:

The latest connection to this idea is a blog post titled “#IamScience: Embracing Personal Experience on Our Rise Through Science” by Kevin Zelnio. Kevin describes his own amazing winding journey to a science career. He too thought he was alone in his odd path, only to find he was surrounded by very common company.

He started the hashtag #IamScience on Twitter as a way for others to describe their journey and the idea quickly spread. Soon hundreds of people created this beautiful common thread of reasons they became scientists and their often contorted ways of getting there. Some of the comments were set to music in this gorgeous video by Mindy Weisberger.

I Am Science from Mindy Weisberger on Vimeo.

So thank you Stephen, Kevin and all the amazing people using #IamScience for putting a real face to what we do. You are all amazing and I am proud to call you my colleagues, no matter how weird you think you are. :O)

Meet a Scientist Monday #21: Liz Warren

21 Nov

Howdy! Today’s Meet a Scientist Monday podcast guest is Gravitational Physiologist Dr. Liz Warren.

Gravitational Physiologist Dr. Liz Warren


Learn more about Human Space Physiology and NASA’s Human Research Program..

Follow Liz on Twitter: @spasmunkey

I hope you enjoyed this podcast of MSM. Please let me know what you think of it, good, bad, or ugly by commenting below.

If you are a scientist/engineer, I would love to have you participate in MSM! Send me an e-mail at: proteinwrangler@gmail.com

To begin Podcast, press the arrow below:

Removing a Broken FPLC Connector

9 Nov

Have you ever snapped off one of those finger-tight connectors on a FPLC valve? Here’s an easy way to remove the broken part from the valve:

You’ll need:
-mini phillips screwdriver (i.e. the kind for fixing glasses)
-lab burner
-paper towels

1.) Remove valve or column from FPLC.

Valve with broken tubing connector (black) still in valve (tan).


2.) Wrap paper towels around the handle of mini phillips screwdriver. Place tip into flame till it turns slightly red. Be careful in handling this by the paper towel wrapped handle. It’s really hot!!

Heating mini screwdriver.


3.) Quickly insert hot end of screwdriver into broken off part of connector. Allow to cool for a minute or so.

Hot screwdriver in broken connector end.


4.) Once cooled, the screwdriver and connector will act as one piece. Unscrew the broken connector out of the valve.

Cooled screwdriver in a broken connector on a desalting column.


Once removed you may need a pair of pliers to wiggle the broken connector off of the screwdriver.

That’s it! You just saved $350 because you didn’t have to buy a new valve kit!

Meet a Scientist Monday #20: Ben Longmier

7 Nov

Howdy! Today’s Meet a Scientist Monday podcast guest is Ad Astra Rocket Company‘s Principal Scientist Ben Longmier.

Ad Astra Rocket Company Principal Scientist Dr. Ben Longmier


Learn more about Project Aether and Space Center Lecture Series.

I hope you enjoyed this podcast of MSM. Please let me know what you think of it, good, bad, or ugly by commenting below.

Many thanks to @avgjanecrafter on Twitter for suggesting Ben be on MSM. If you are a scientist/engineer, I would love to have you participate in MSM! Send me an e-mail at: proteinwrangler@gmail.com

To begin Podcast, press the arrow below:

Meet a Scientist Monday #19: John Coupland

23 Oct

Howdy and welcome to Meet a Scientist #19!! Today’s scientist is Dr. John Coupland Professor of Food Science at Penn State University.

Penn State's Professor of Food Scientist Dr. John Coupland


Follow John on Twitter at @JohnNCoupland

Check out John’s blog at “Chemicals in My Food”

I hope you enjoyed this podcast of MSM. Please let me know what you think of it, good, bad, or ugly by commenting below.

If you are a scientist/engineer, I would love to have you participate in MSM! Send me an e-mail at: proteinwrangler@gmail.com

To begin Podcast, press the arrow below:

Are Big Home Sources Dead? Test Driving Rigaku’s New ScreenMachine

20 Oct

As any crystallographer knows, home sources are expeeeeensive. Combine the cost of the unit, it’s components, a dedicated room, a dedicated technician and a service plan, who can afford these multi-million dollar devices? Big Pharma can. Academia sometimes can, but only if the costs are spread across multiple big money PIs. While almost all synchrotrons now have automation, sending them 200 crystals for cryo screening seems like shooting a gnat with a .44 Magnum.

Our lab doesn’t have a home source. For the past 3.5 years, we have been home source gypsies, going from lab to lab in the local vicinity just to see if something diffracted. And by vicinity I mean all over the city. Believe me, transporting xtals in your car on Houston roads is a real thrill.

To possibly cure us of our vagabond ways, we recently visited Rigaku to demo their new compact home source called The ScreenMachine. On first look, you want to know where the man behind the curtain is, because this thing is small. At maybe 5.75 ft tall by ~4ft wide, I would not have guessed it was an x-ray source. The unit is shielded and on wheels, so no special room is needed. Power requirement is through a standard 110V outlet. Nice, huh?

Rigaku ScreenMachine (No wizard behind the curtain. Yes, I looked.)


The next wow factor was mounting on its inverted single phi and using an iPad for centering. Awesome. If I wanted to, I could e-mail grandma while mounting crystals. The ScreenMachine comes bundled with HK3000 (not on the iPad, of course) and equipped with a 75mm CCD detector, Oxford 700 cryostream, and a sealed tube 30W x-ray generator with 90 µm FWHM.

Mounting a crystal in the ScreenMachine


While this stripped down, no frills set-up may raise an eyebrow on the purists out there, I liked it. Basic, compact, fast and easy are positive attributes when screening a lot of samples. Does it have ice rings or diffract? No. OK. Next crystal.

A Rigaku rep came by about a week before our visit and picked up our crystals. We had given them several crystal types to run on the ScreenMachine, some known to diffract well and others that didn’t, with a size range of ~80-150 um. We were surprised to find when we arrived that Rigaku had actually collected several full data sets on some of them.

We asked if we could run these same crystals on their big home source to compare the two and Rigaku was cool enough to do so. Of course, there was slightly better diffraction, but overall the two data sets had comparable I/sigI. Not bad at all.

Example of one of our ScreenMachine test runs. Outer diffractions are ~2A


The cons are slight: Yes, the source isn’t the strongest, but for initial screening it’s perfect. Also, this is the first version of The ScreenMachine and I’m sure there are some unseen bugs, but Rigaku did some pretty stringent ringing out of this machine and I’m certain they are slight. That didn’t stop you from buying the first version of the iPad did it? :O)

Fast screening, with the option to collect a full data set is pretty nice. Driven by large HTC structure mills (i.e. PSI, etc) I really think this will be the future of home sources, with the next generation machines becoming smaller and more automated. I look forward to having a bench-top x-ray source to screen with one day. What’s next? A bench top NMR?

Cycles

12 Oct

Tags: ,

Meet a Scientist Monday #18: Stephen Curry

3 Oct

Howdy and welcome to MSM #18! Today’s guest is Dr. Stephen Curry of the Imperial College of London.

Crystallographer and blooming Film Director Dr. Stephen Curry

Please enjoy Dr. Curry’s film “I’m a Scientist”

Follow Dr. Curry on Twitter: @Stephen_Curry

I hope you enjoyed this podcast of MSM. Please let me know what you think of it, good, bad, or ugly by commenting below.

If you are a scientist/engineer, I would love to have you participate in MSM! Send me an e-mail at: proteinwrangler@gmail.com

To begin Podcast, press the arrow below:

List of Micro-gravity Crystallography Journal Papers

1 Oct

Simply a list of Micro-g crystallography journal citations I have collected. I’ll update it as I find more. If you have any you would like to add, please let me know in the comment section.

Micro-g xtals citation list html

Micro-g xtals citation list rtf

Micro-Gravity Protein Crystallography Experiments Flown on Space Shuttle

17 Sep

Since flying my crystallography experiments on STS-134 and 135 I’ve been really interested in seeing what else has flown in the past. Searching press releases from shuttlepresskit.com, I compiled a list of protein crystallography experiments flown on the shuttle.

HTML format: Micro-g Crystal Research
Excel format: Micro-g Crystal Research

A few quick observations:

  • The first documented protein crystallography experiments to fly on shuttle was a GAS can payload on STS-41B
  • The Russians and ESA dabbled a bit, but the University of Alabama’s Center for Macromolecular Crystallography (now The Center or Biophysical Sciences and Engineering (CBSE)) dominated the field.
  • The equipment and techniques reached a pretty mature level with three or four often used devices.
  • A lot of different proteins flew, yet most of them were standards.
  • Pharma flew samples, but I don’t know of any available info of their results or what they flew.
  • Micro-g protein crystallography on shuttle stopped with STS-101.

Please let me know of any errors or additions. My next little project is to make a list of ISS experiments and a list of publications of micro-g protein crystallography.

My Six Months on Twitter

5 Sep

I was very resistant to the whole idea. Cautious by nature, I’m especially slow to adopt anything that large groups of people are doing. Why would anyone care what I was doing? Why would I care about what everyone else was doing? Isn’t Twitter just full of celebrities and egotistical people?

After over 2,000 tweets, I guess I was wrong. I like it. A lot. I have the attention span of a cat and love the steady stream of information that flows through my timeline. The mood is always fun and positive. I have experienced shuttle launches, hurricanes, earthquakes, new restaurants and made a lot of new friends in the past six months. The experiences are through real people, not the bubble headed bleach blonde that comes on at five. And before you say “What friends? They’re all make believe on a web site?” Let me say two words: Tweet Up.

Tweet Ups are where a group of Twitter users (called Tweeps) with a common interest, meet somewhere for an activity. Probably one of the most varied and dynamic groups I have had distinction of interacting with is the Space Tweep Society. Through them I have re-newed my faith in humanity becoming a space fairing species. I also found that I’m not alone in having the entire Shuttle launch sequence memorized.

There are a lot of scientist on Twitter. From PI’s to lowly grad students, there are a lot of disciplines and personalities represented. Out drinking to celebrate getting a paper published in Nature? Add the #drunksci hashtag and you’ll have others to congratulate you. Ever had a problem with an assay that you just can’t figure out? Tweet away and someone just may tweet back a suggestion. At the very least you’ll have others to commiserate with and suggest a good place to become a #drunksci.

So, after six months I am quite happy and I look forward to reading and meeting other Tweeps. If you are on the fence, give it a try. You just might like it.

You can follow me on Twitter at: @ProteinWrangler

If you are new to Twitter here are some definitions and a list of some of the personalities you might meet. Also included are the lists I have created.

Definitions

    RT = re-tweet
    MT = modified Tweet (edited to fit into 140 characters).
    OH = overheard
    #FF = follow Friday. Tweeps list Tweeps they think are cool and that you might want to follow.

My Lists

Personalities

  • HottieBots
  • Sadly, there is spam on Twitter. HottieBots seem to be one of the most prevalent types. I highly advise ignoring them. HottieBot solicitations include a profile pic of an attractive woman with your twitter name and a link. I’ve never clicked on a link so I don’t know what they are selling, but I’m sure it’s nothing I want.

  • Salespeople
  • These people can be spotted by having a large number of people they follow, a small number of followers, and lots of tweets. Their tweets are usually repetive sales tweets.

  • Companies
  • A lot of companies now have Twitter accounts. Some are Spam. Some of them are kinda boring and don’t interact much with other Tweeps. Some are really fun. I have interacted with a few of the science companies and actually gotten some first hand help with assays. You’ll also find you’ll get “followed” by a company after you tweet about a product, say movies or Starbucks.

  • Celebrity Tweeps
  • Actors, reporters, musicians, artists, etc. Thousands to millions of followers, follow very few. It’s all about them, so expect little to no interaction.

  • Fake Celebrities
  • I actually find a lot of these pretty funny. Real celebrities have a blue check next to their names.

  • Twitter Celebrity
  • Very popular on twitter, but no where else. Think: popular kids in high school. Lots to say and only interact with a small circle of Tweeps.

  • Lurkers
  • Follow lots of people, have very few followers, few to no tweets. Use Twitter as a news source, but don’t care to interact.

  • Messengers
  • Constantly re-tweet the content of others (i.e. celebrity tweeps, news stations, etc) and links to stuff they find interesting.

Opportunities for science in space will continue, Methodist researchers say

23 Jul

Media contact:
David Bricker
The Methodist Hospital
832-667-5811
dmbricker@tmhs.org


FOR IMMEDIATE RELEASE

Houston — (July 22, 2011) — Although disappointed by the retirement of the Space Shuttle program, a former astronaut and a biochemist who has flown experiments aboard the last two U.S. space shuttle missions both believe the outlook on research in a near-zero gravity environment should remain optimistic.

Scott Parazynski, M.D., chief medical officer and chief technology officer for The Methodist Hospital Research Institute, has flown on five shuttle missions (STS-66, STS-86, STS-95, STS-100, and STS-120). He says researchers will increasingly rely on the International Space Station (ISS).

“The ISS is enhanced with six full-time crewmembers to operate experiments,” Parazynski said. “American researchers will have continued access to space — even without the space shuttle to fly crews and scientific payloads — using a variety of spacecraft from the U.S., such as SpaceX, Orbital, and Boeing, as well as spacecraft operated by programs based in Russia, Europe, and Japan.”

Carl Carruthers, a research assistant in the lab of John Baxter, M.D., and Paul Webb, Ph.D., who study diabetes-related proteins for the Research Institute, agrees the opportunities for conducting experiments in microgravity aboard the ISS or in collaboration with other space agencies’ programs are going to increase.

“In part because of the work of contractors, who act as go-betweens to secure room for these experiments with various partners around the world, the entire process is becoming faster and easier than ever before,” said Carruthers, a biochemist. “It’s sad to see the end of the U.S. shuttle program, but it doesn’t mean American scientists who need access to microgravity will struggle to see their projects completed. It doesn’t mean that at all.”

Carruthers said businesses that negotiate on scientists’ behalf for access to the ISS have helped make the end of the U.S. shuttle program a non-issue for conducting research in space. Houston-based NanoRacks LLC has served that function for NASA’s most recent shuttle missions, and will continue to facilitate science projects for the U.S.-operated segments of the ISS by arranging for American scientists’ projects to be flown up by other means.

“The ISS is an excellent facility and it’ll be up there for a long time,” he said. “Unlike the space shuttles, which were never really intended to be science machines, the ISS is highly dedicated to scientific research. If anything, it’s under-utilized.”

Carruthers has been looking at how diabetes-related proteins crystallize in microgravity. The formation of protein crystals is crucial to an analytical technique called protein crystallography, which is used to determine the shape, structure, and function of proteins. Understanding proteins through-and-through helps medical scientists design new drugs that more effectively alter the proteins’ behavior.

Carruthers had experiments flown on U.S. Space Shuttle mission STS-134 in May (Endeavor), and has a similar experiment on the current shuttle mission, STS-135 (Atlantis), scheduled to end later this month. As part of an education outreach initiative, Carruthers has been working with Broward College Professor Rolando Branly and student researchers to analyze the crystals and gather data. Equipment and sample integration is provided/ by Instrumentation Technology Associates, Inc. (ITA) and NanoRacks LLC arranged for the mid-deck locker facilities aboard Atlantis.

Parazynski and Caruthers aren’t the only Methodist researchers with an interest in microgravity. In 2009, a team led by Research Institute President and CEO Mauro Ferrari, Ph.D., and Department of Nanomedicine Co-Chair Alessandro Grattoni, Ph.D., won the Heinlein Prize Trust’s Microgravity Research Competition. The scientists were given a prize and, in collaboration with the private space exploration company SpaceX, the opportunity to study the physical chemistry of drug release in low orbit.

Both Parazynski and Carruthers were present for the launch of STS-135 on July 8.

Carruthers receives funding for his experiments from the National Institutes of Health and The Methodist Hospital Research Institute.

To speak with Carruthers or Parazynski, please contact David Bricker, The Methodist Hospital, at 832-667-5811 or dmbricker@tmhs.org.